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Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention. However, the following examples are provided to further understand the present invention, and the present invention is not limited by the examples.

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Substantial consumption of alcohol e. Tadalafil 10 mg or 20 mg did not affect alcohol plasma concentrations and alcohol did not affect Tadalafil plasma concentrations. Ritonavir initially inhibits and later induces CYP3A, the enzyme involved in the metabolism of Tadalafil.

The randomized, double-blind trial aims to recruit participants to be given either Adcirca or a placebo for six months. Patients also will be given the option to enroll in a two-year extension study.

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In all the batches, micronized Tadalafil was mixed with speciality excipient and lactose one-third quantity to achieve uniform distribution of micronized drug before wet granulation. B5 and B6 were processed using direct compression.

Tadalafil is an active ingredient in a FDA- approved prescription drug that is used for the treatment of male erectile dysfunction. The presence of Tadalafil Mero Macho renders it an unapproved drug for which safety and efficacy have not been established and, therefore, subject to recall.

The reason why the dissolution rate of tadalafil is low is due to the low solubility of tadalafil. However, in the oral liquid formulation of the present disclosure, tadalafil was completely homogeneously diluted with the dissolution solution at the time of initiation reasons of ED the dissolution, and the dissolution rate thereof was high, namely Test Example 5: Pharmacokinetic evaluation. The oral liquid formulation of Example 1 was orally administered to four rats and the pharmacokinetic properties thereof were evaluated.